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10.3389/fphar.2022.918531 32 FornaroM.AnastasiaA.NovelloS.FuscoA.ParianoR.De BerardisD.et al (2019)

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1 Introduction 1.1 The intrinsic disorder phenomenon in a few words Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) do not have unique rigid structures that typically observed in globular proteins/domains

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Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements