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People suffering peripheral neuropathy in their legs and feet applied CBD cream or placebo for one month

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Furthermore, elevated cytosolic aconitase (c-ACNT) and isocitrate dehydrogenase (ICD2), synergistically enhanced by iron accumulation, drive citrate flux toward NADPH and -KG generation, thereby exacerbating intracellular citrate depletion

To the contrary, high to normal levels of circulating IGF-1 correlate with a rise in adiponectin levels and a reduced prevalence of MetS is found [233]