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While Epithalon did not significantly influence food consumption, body weight, or mean life span, it did slow down the age-related switching-off of estrous function, decreased the frequency of chromosome aberrations in bone marrow cells, and significantly increased the maximum life span (by 12.3%) and the life span of the last 10% of survivors (by 13.3%)

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These effects occur despite BPC-157 not directly increasing VEGF-A expression, suggesting the peptide works primarily through receptor sensitization rather than ligand upregulation

Opposite Effects of Statins on Mitochondria of Cardiac and Skeletal Muscles: A mitohormesis Mechanism Involving Reactive Oxygen Species and PGC-1