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Due to the effects of increasing antioxidant and reducing free radicals following the administration of this drug (18), the role of this drug in improving insulin secretion following the regulation of its receptor activity, reducing fat tissue, preventing and improving endothelial damage and ischemia, inhibiting phospholipid metabolism and also regulating the process of releasing pro-inflammatory cytokines has been noted (19, 20)
The palate and maxillary gingiva are involved in approximately 80% of patients, but buccal mucosa, mandibular gingiva, and tongue lesions are also identified
Moreover, the gut microbiota and its associated metabolites promote the differentiation and function of anti-inflammatory macrophages, Treg cells, CD4 + CD8 + regulatory cells, IL-10 + and/or IL-35 + B regulatory cells, as well as IL-22-producing innate lymphoid cells 3 (ILC3), which are involved in maintaining the gut mucosal homeostasis (Su et al., 2022) and protecting the kidneys (Su et al., 2022)
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