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Blistering and photosensitivity improve with age, while poikiloderma and skin atrophy persist.3 Around 10% of patients with KS can develop malignant skin tumors,1,11 such as squamous cell carcinoma, after 45 years of age.5 The mechanism underlying carcinogenesis may be related to low levels of transforming growth factor and increased Wnt signaling, both of which have been described in humans and mice with KS.12,13 The use of sunscreen and protective clothing is essential to minimize the risk of carcinogenesis in these patients, especially in countries with high levels of solar radiation, such as Peru.3,13 Involvement of the mucosa, especially the oral mucosa (85%), is frequent
These symptoms can be overwhelming and difficult to manage without professional assistance
The main finding is respiratory failure Respiratory failure Respiratory failure is a syndrome that develops when the respiratory system is unable to maintain oxygenation and/or ventilation
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Initially, it may help to avoid these triggers until you feel more confident in your ability to manage cravings