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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

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In the study by Neelakantan et al

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In preclinical research settings, NNMT modulation is investigated for its downstream influence on NAD + -related biochemical pathways and cellular energy regulation