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The trend for smoking cigarettes would continue to rise in the early 20th century

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10.1371/journal.pone.0268746 [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Lyytinen G, Melnikov G, Brynedal A, Anester E, Antoniewicz L, Blomberg A, et al

Because synthetic nicotine isnt derived from tobacco, it evaded the regulatory authority of the FDA until April 2022, says corresponding author Traci Hong, a Boston University Professor of Communications and Hariri Institute Research Fellow