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GPX4 expression can also be directly inhibited by IR [39, 44, 45, 48, 50, 52, 53], suggesting a role IR may play in limiting both GPX4 levels and activity

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Immunofluorescence results showed a significant increase in FOXO4 and p53bp1 foci within the nucleus of senescent cells compared to those in dividing cells (Figure

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618 More recently, a new riboswitch class, exemplified by the DUF1646 motif, was characterized to selectively sense Na I and regulate the downstream expression of sodium and calcium transporters among other genes relevant to sodium biology