15 Pederzini et al
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This increased risk is due to the formation of highly susceptible trans-encoded DQ heterodimers (58, 60)
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As part of the glutamate-glutamine cycle, astrocytes and oligodendrocytes take up the neurotransmitter glutamate released from neurons at synapses, metabolize it to glutamine using GLUL, and then export it back to neurons, where glutamine is converted back to glutamate using glutaminase (GLS)
A more recent study [23] included FEP subjects with up to 2 years of illness duration, while we recruited all subjects during the acute first episode (mean SOFAS score of 38.1)