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Another study in the Journal of the American Medical Association notes that among those with diabetic nephropathy (loss of kidney function due to diabetes), combining vitamin B6 (25 mg) and folic acid (2.5 mg) (B-complex vitamin) with 1,000 mcg of oral B12 per day for six years increases the risk of cardiovascular events, including heart attack and stroke

Clinical research validates this targeted approach

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Precautions General Precautions: Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord

It provides reasonable precision at 0.25 mg (7.5 units) and manageable volumes at 2.4 mg (72 units)