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For adult smokers who have been unable to quit through other means, the evidence from the National Academies of Sciences and multiple federal health agencies supports the conclusion that a complete switch from combustible cigarettes to e-cigarettes reduces exposure to the toxicants and carcinogens most responsible for smoking-related disease

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

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