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2009 Sep;137(3):81523

The physiological difference between those two scenarios is enormous particularly for someone whose estimated BAC is near the legal threshold

274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)