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For topical use, transient local reactions redness, stinging, burning, or itch are the expected category and are exactly what the ongoing Phase 2 trial is set up to measure (NCT07437586)

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In fact, research suggests it can improve memory and learning processes, especially under conditions of emotional stress

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They also are sensitive to environmental conditions and can change chemical composition if stored at the wrong temperatures or shaken too vigorously, increasing the risk of an immune response or decreasing their effectiveness