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2011 Aug 17;133(32):12493-506

With a few drugs, such as phenylbutazone, ethanol, deracoxib, and phenytoin, or if very large doses of a drug are given, the drug concentrations achieved are much greater than K m and the rate equation is as follows: The enzymes are saturated by the high free drug concentrations, and the rate of metabolism remains constant over time

Supplementary material The Supplementary Material for this article can be found online at: References Chen J., Wang M., Joyce A., DeFranco D., Kavosi M., Xu X., et al

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