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IGF-IR promotes epithelial-mesenchymal transition (EMT) and stemness It is conceived that dynamic EMT and mesenchymal-epithelial transition drive cancer cell invasion, survival in circulation, and outgrowth in secondary organs

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Exposure can also occur through non-water sources, such as food grown with arsenic-contaminated water or cultivated in polluted soil, which poses a substantial health threat, particularly in regions with affected groundwater

doi: 10.1016/j.freeradbiomed.2024.12.007

At higher concentrations, cocaine also blocks different voltage gated channels in a state-dependent manner with a higher affinity for inactivated and open states vs rested/closed states of the channels

Therapy-induced senescent cells can re-enter the cell cycle to show aggressive proliferative and cancer stem-like properties, presenting a risk for recurrence and treatment resistance