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Archived (PDF) from the original on October 17, 2021

11, 29 Although it is unclear whether the accumulation of iron in the brain is primary or secondary to the development of neurodegenerative disorders, 30 one animal study has shown that unilateral injection of FeCl 3 into the substantia nigra of adult rats results in a 95% decrease of striatal dopamine, which impaired dopamine-related behavioral responses

As demonstrated in the extant literature, in circumstances where glutamine is depleted, tumor cells have been observed to circumvent glutamine metabolism, instead relying on asparagine to sustain their growth [216]

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In one embodiment, the buffer is a sodium bicarbonate buffer having a pH of about 7.5 to about 8.5