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And I've covered this before, but Ian hypothesizes within our genetics, we share an ancestor with the eternal jellyfish

The high reactive oxygen consumption by the brain enhances the brains susceptibility to oxidative stress to which endothelial cells are more sensitive compared to pericytes, and pericytes are more sensitive than astrocytes [82]

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Wnt 7a and 7b are the signals that induce the formation of the BBB and are also involved in BBB repair