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Similarly, the aetiology of irAEs is akin to those that promote the anti-tumour effect and mainly involves the expansion of the T cell repertoire

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Frias J.P., Deenadayalan S., Erichsen L., et al

Aromatase is an enzyme that converts androgens into estrogens

The FDAs decision was based on the Phase III APPLAUSE-IgAN study, in which treatment with Fabhalta cut proteinuria by 44% through nine months of follow-up, while placebo comparators saw only a 9% reduction in proteinuria