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The relationship between fascia and knee OA is a 2-way street knee OA impacts fascia, making it denser and more fibrous, and reducing its gliding properties, while fascial restrictions can impact knee mechanics

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Common hypotheses point to genetic predisposition plus environmental triggers

Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and / hydrolases

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