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This lesion is most commonly seen in older male tobacco users who smoke pipes but it also can be found in cigar and cigarette smokers

J Appl Physiol (1985) 2001;90(3):816820

In fact, smoking can counter the effect of blood pressure medications like beta-blockers

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Proctor (December 1996), "The anti-tobacco campaign of the Nazis: a little known aspect of public health in Germany, 193345", British Medical Journal , 313 (7070): 14501453, doi:10.1136/bmj.313.7070.1450, PMC 2352989, PMID 8973234 "Research on Smoking and Lung Cancer: A Landmark in the History of Chronic Disease Epidemiology"