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Impaired energy metabolism in ME/CFS Even though an exact metabolic phenotype has not been established (185), a stressed metabolism is present in ME/CFS

Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

doi: 10.1016/j.autrev.2020.102647 169 SchneiderALongSACerosalettiKNiCTSamuelsPKitaMet al