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First, the number of dimensions were reduced using time-structure independent component analysis (tICA) 63,64

Additionally, conditions such as severe cardiac or pulmonary insufficiency that lead to reduced peripheral perfusion, lactic acidosis, liver disease, alcohol dependence, or the use of intramuscular contrast agents for radiographic imaging also represent exclusion criteria due to the increased risk of adverse effects, particularly lactic acidosis (80, 121)

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10.1016/j.ejphar.2015.10.023 64 HeM.MinJ.-W.KongW.-L.HeX.-H.LiJ.-X.PengB.-W

4 encode cytosolic GST and one encodes the microsomal form of GST