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In some embodiments, the otic formulation or composition comprises about 0.03% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

It is plausible the IP method induced a mild, transient toxicity that improved maze times through acute stress-arousal rather than genuine neural rejuvenation

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In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation

Are injections the only effective route for BPC-157? This is not always the case