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GTPSCS translocates into the nucleus depending on a nuclear localization signal in the GTPSCS G1 subunit and acetylation at residue K73 of the G2 subunit and interacts with p300 to synergistically regulate H3K18la

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Chloroquine Hydroxychloroquine (HCQ) and chloroquine (CQ) have clinical applications for prevention and treatment of malaria and have been repurposed to treat milder manifestations of SLE, such as skin rash and arthritis (172)