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The procedure is typically performed using local anesthesia in a physicians office or ambulatory surgery center

The UFE Procedure The UFE procedure is performed by an interventional radiologist

While the passive technique focuses on drug and vehicle interaction and optimization to affect the stratum corneum structure, the active approach utilizes external energy to facilitate the transportation of drugs through the skin or by physically disrupting the outermost layer of the skin, known as the stratum corneum [230, 231]

Available in three concentrations (0.3%, 1.0%, 1.6%), Retinol Charisma enables practitioners to better manage treatment intensity and tailor clinically effective retinol-based protocols with reduced irritation