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Consequently, GPX4 is unable to utilize GSH to convert lipid hydroperoxides into lipid alcohols, leading to an inability to effectively clear ROS and lipid reactive species generated by lipid membrane damage, disruption of the mitochondrial electron transport chain, and potentially by iron release from iron-containing enzymes

For TXN-II, different interactors were identified under physiological and oxidative stress conditions, and it was suggested to influence the proteins involved in energy metabolism and cytoskeleton and protein translation (Arias et al., T

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