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Many protocols combine both approaches for maximum effect, typically running 12 to 16 weeks minimum before visible density changes become apparent

The system is still building toward steady state

ALS patients exhibit increased expression of BM components like collagen IV, whereas model mice show a reduction in collagen IV [241, 242]

reported improvements in clinical attachment level (CAL), probing depth (PD), gingival recession (REC) , and probing bone levels, after using hyaluronic acid hydrogel scaffolds enriched with fibroblast growth factor type 2 (fhFGF-2) in the surgical treatment of periodontal intrabony defects

FEBS Letters , 238(2), 343346