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doi: 10.1016/j.ijbiomac.2022.04.024 34 SoaresMPHamzaI

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Once inside, the unprotonated amphetamine molecules become rapidly protonated by the acidic environment of the vesicle, which alkalinizes the vesicle matrix and completely dissipates the necessary pH gradient (Wimalasena 2011)(see Figure 2 Mechanism A)