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It has been studied for its role in supporting skin appearance and overall skin health for several decades in regenerative medicine literature

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Proc Natl Acad Sci USA 79:24602464 Messana I et al (2000) Blood bank conditions and RBCs: the progressive loss of metabolic modulation

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doi: 10.1038/s41598-023-46057-4 118 HerreraFGRonetCOchoa de OlzaMBarrasDCrespoIAndreattaMet al

Also, numerous processes, inflammation, innate immunity, apoptosis, and cell proliferation, for instance, are mediated by it [57]