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In aged mice treated for 8 weeks at 10 mg/kg daily, sedentary mice showed approximately 40% greater grip strength than controls, and when combined with exercise, grip strength improved by approximately 60%

Human safety data is limited, so its full risk profile is not established

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Long-term safety data beyond 24 weeks is limited

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Some compounded tirzepatide formulations include B12 (methylcobalamin), and researchers report improved energy levels with this addition