melanotic macules on tongue Smokers melanosis . Oral pigmentation seen in heavy smokers . Investigations have shown ability of melanin to bind to noxious substances. . Exposure to polycyclic amines ( Nicotine & benzpyrene) has shown a) Lingua villosa nigra in

118 However, a post-hoc analysis of Statins use in a randomized controlled trial revealed that Statins therapy was safe for patients with prediabetes or T2DM and NASH, suggesting Statins may be a potential therapeutic strategy in those patients

doi: 10.1038/s41580-020-00324-8 76 ConradMSatoH

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BioengineeredC-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway

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These markers include oligomeric antibodies and amyloid plaque load