Zhou L, Chen Y, Gao J, Shankar S, Zhang G
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Afterward, the remaining peptides in the samples were analyzed by C18 reversed-phase high-performance liquid chromatography (HPLC) and detected at 220 nm
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This led to the discovery of NP-BTA, a N-pyridinyl--thienyl-acrylamide derivative, was discovered to inhibit the essential enzyme glutaminyl-tRNA synthetase (Gln4), representing a novel antifungal mechanism of action (Fu et al., 2021)
The accumulation and deposition of A in the brain appears to occur early in Alzheimers disease and triggers other processes that lead to dementia, including tau phosphorylation, inflammation, synaptic dysfunction, and neuronal loss (213, 216)