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(2018) 48:e13012

The ERO1-PDI axis is thought to be the main pathway for disulfide bond formation in ER ( 2 in the presence of flavin cofactors, which are then passed to the protein for folding via PDI ( 2 O 2 produced by Ero1 to accelerate the oxidative folding process of proteins in vitro and in vivo (Figure 6)

10.1007/s00228-023-03461-z 41 ForetzM.GuigasB.ViolletB