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Mucus dehydration, mucus hypersecretion, and chronic inflammation are hallmarks of the chronic bronchitis component of COPD and they all contribute to the progressive/irreversible airflow limitation, increased chances of infection, and lung destruction seen with this disease 6

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The carcinogens in tobacco smoke contribute to cancer development in both directly exposed and distant tissues

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In young people, using menthol cigarettes and cigars first is associated with continued cigarette use

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