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We projected that for molecules whose accumulation was impeded by the OM, there would be an increase in apparent accumulation after the passage was improved

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Court MH and Greenblatt DJ

In some embodiments, the otic formulation or composition comprises about 0.03% by weight of the silicon dioxide

Pharmacologic inhibition of FSP1 provided notable therapeutic benefit in preclinical lung cancer models, and FSP1 expression had prognostic associations in lung cancer, supporting translational relevance 80

Rath, T., Dieterich, W., Ktscher-Murad, C., Neurath, M