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For example, administration of the cysteine-donor N-acetyl cysteine (NAC) in humans significantly increases blood [6264] and muscle [65, 66] GSH levels, and in vitro studies show methionine supplementation to have beneficial effects on GSH hepatocyte concentrations [67]

Hydroperoxyl radicals (HO) HO, a form of ROS, forms as an intermediate radical through the protonation of O 2 [50]

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10.1016/s0022-5347(05)65253-6 32 CabralG

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