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Interestingly, a recent study examining the time-dependent effect of low IGF-1 levels on aging outcomes observed that a targeted reduction in liver-derived IGF-1 early (10 d or 5 mo) or later in life (15 mo) improved aspects of lifespan in females, though these effects were most pronounced when IGF-1 was reduced at 5 mo old 19

4 The majority of post-surgery arthroplasty patients are also prescribed opioids

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After 2 days, the dosage was tapered off to 62 mg/24 h for 2 days

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31 Considering the bioavailability of ketamine, this was a mean dose of approximately 10 mg, which is lower than what is typically used for pain treatment