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Researcher synthesised demethoxycurcumin and bis-demethoxycurcumin, in HERr2 + cells and MCF-7, the phytochemicals were discovered to limit cancer cell proliferation, as shown by an IC50 value below 10 M ( in vitro IC 50 concentrations may not directly reflect clinically achievable plasma or tissue levels, and translational interpretation requires pharmacokinetic validation

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However, in individuals with NAFLD, alterations in the gut microbiota can disrupt the balance of SCFA production, exacerbating fibrosis, insulin resistance, and hepatic steatosis[68]