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GeroScience 48 , 20852100 (2026)

However, other studies have shown that TGF-1, through Smad3 activation, inhibits the expression of the glutamate-cystine antiporter system Xc-, enhancing lipid peroxidation levels in PLC/PRF/5, Huh7, Huh6, and Hep G2 cells marked by early TGF-1 genes, but not in cells marked by late TGF-1 genes [122]

They act centrally in the hypothalamus by reducing appetite and increasing the feeling of early satiety

LPCAT3, conversely, presents a context-dependent role, acting as either a pro- or anti-ferroptotic modulator depending on the OA stage or inflammatory milieu

Beyond modulating the metabolic and immune environments of tumors, targeting tumor matrix remodeling has emerged as a novel therapeutic strategy

BPC-157 The peptide BPC157, derived from human gastric juice, is used to relieve bone and joint pain including wound healing