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A 2007 study showed that the addition of alkali forming elements in potassium-magnesium citrate is an effective tool to reduce kidney stone formation

Reduce temperature cycling by avoiding repeated warming and refreezing when possible to preserve integrity

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10.1074/jbc.M117.785394 78 KitykR.KoppJ.MayerM

For example, rodents, which are commonly used in animal studies, possess distinct lipid metabolism patterns compared to humans, potentially leading to discrepancies in the efficacy and safety profiles of metabolic modulators as research transitions from animal models to human applications (140)