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Moreover, in an in vitro model of blast-induced auditory hair cell damage, 3-AB inhibition of PARP1 reduced oxidative stress markers, upregulated antioxidant defenses, and helped maintain cell viability by preserving ATP pools 175

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202,203 In vivo, astrocytes are more sensitive to periods of ischaemia, although they still tolerate them better than neurones

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Nausea, vomiting, reduced intake, constipation, diarrhea, dizziness, or dehydration can become more important if several agents are used together