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The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration

Group 2 was diabetic untreated (DU), group 3 received magnesium (250mg/kg) orally (DMg250) while group 4 received insulin (3IU s.c) (DI) for 21days respectively

Regarding pro- and anti-apoptotic protein levels, Bax expression was elevated across all treatment groups relative to control but did not reach significance, while Bcl-2 expression trended higher in all DOX and DOX + GHRP-6 groups but again failed to reach significance

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