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Signal Peptide Activity and Fibroblast Stimulation In-vitro studies on cultured dermal fibroblasts have consistently reported that GHK-Cu exposure at nanomolar to low-micromolar concentrations restores proliferative capacity in senescent or irradiated cells [2][3]

The GCG gene promoter region contains an enhancer that harbors a canonical Wnt response element that binds TCF factors, in particular the TCF7L2 protein