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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

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In this article, well break down what the science says about nicotine and blood pressure , explain the short-term and long-term effects of vaping on hypertension , highlight common symptoms , and share practical tips to reduce risks