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Prevalence rates differ significantly based on age, gender, racial or ethnic background, and specific diagnostic criteria

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Choi IS, An C, Swisher SG , Correa AM, Ajani JA, Rashid A, Hamilton SR, Wu TT

Research indicates that polyphenols and exercise independently reduce circulating (plasma) pro-inflammatory cytokines such as IL-1 and TNF- while also modulating brain-derived neuroinflammatory markers (e.g., microglial activation and astrocytic response in hippocampal tissue), contributing to improved cognitive and mood-related outcomes [238, 239]

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