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IL-1 and TNF- stimulate chondrocytes and synovial cells to secrete MMP-1, MMP-3, and MMP-13, which degrade collagen and proteoglycans in the cartilage matrix, worsening cartilage damage (150, 151)

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A total of 77.7 GB of raw data (the RNA-Seq raw data were uploaded to NCBI, with the accession number PRJNA822859) were generated from these samples (4 repeats for each stage)

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However, RhoA inhibition partially mitigated these alterations (Fig