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In addition to their role in promoting breast cancer cell proliferation [67] and mediating inflammation [68], breast CAFs deposit collagen type I and fibronectin [58], secrete matrix metalloproteinases (MMPs) [69], and promote collagen crosslinking (e.g., via lysyl oxidase (LOX)) [70]

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Experimental Results: Bone density: The lumbar spine BMD in the elderly control group decreased by 32% compared to the younger group

Journal of Clinical Medicine (2020) 6

Nevertheless, injections are still considered a reasonable starting point because they can foster a more rapid recovery and because even a temporary improvement in symptoms can corroborate a presumptive diagnosis.

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