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These side effects include cataracts, steroid-induced diabetes, and bone problems such as osteoporosis and avascular necrosis (AVN), a condition in which the bone dies due to inadequate blood supply

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Skin reactions can include flushing or generalised itching

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In published preclinical work, KPV has been studied for inhibiting NF-B activation in intestinal epithelial cells, with one widely cited study showing PepT1-mediated transport into colonic cells as part of its anti-inflammatory mechanism in mouse colitis models (Dalmasso et al., Gastroenterology , 2008)