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Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

The pain signal has been turned down, but the tissue has not knitted back together yet

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Data from over 5,400 women treated between 2016 and 2023 shows that only 17% of women seeking menopause-related care received prescription treatment for their symptomswith dramatic variability across provider specialties

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Dusart J