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A meta-analysis in 2020 of 587 women in 9 studies examined the use of probiotics or synbiotics (a combined supplement of prebiotics and probiotics) in women with PCOS

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211,212 This underscores the importance of identifying and treating underlying causes of sleep disturbance, such as restless leg syndrome

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CLINICAL RELEVANCE OF DRUG METABOLISM The dose and frequency of administration required to achieve effective therapeutic blood and tissue levels vary in different patients because of individual differences in drug distribution and rates of drug metabolism and elimination

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